Depakote is the brand name for divalproex sodium (also known as valproic acid), an anti-seizure drug used to treat epilepsy, some mood disorders (like bipolar disorder), and migraine headaches. Do not take Depakote (divalproex sprinkle capsules) to prevent migraine headaches if you are pregnant. If you are pregnant and take Depakote (divalproex sprinkle capsules) for seizures or bipolar disorder, talk to your doctor to see if you need to keep taking Depakote (divalproex sprinkle capsules). Depakote Sprinkle Capsules (divalproex sodium delayed release capsules), for oral use 125 mg, are white opaque and blue, and are supplied in bottles of 100 (NDC 0074-6114-13) and Unit Dose Packages of 100 (NDC 0074-6114-11). Rated Depakote for Migraine Report. I take 250mg twice daily for migraine! and it has been so great! I have no headaches! but i wouldn't quit cold turkey, it made my migraines come back with force! How to use Depakote Sprinkle. Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking divalproex sodium and each time you. What happens if I miss a dose (Depakote, Depakote ER, Depakote Sprinkles)? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. DO NOT TAKE Depakote and Depakote ER for the prevention of migraine headache if you are pregnant. Talk with your doctor or other healthcare professional about how you should take Depakote, Depakote ER, or Depakote Sprinkle Capsules for epilepsy) and what to expect from your treatment. Depakote Sprinkles side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Take Depakote or Depakene exactly as your healthcare provider tells you. Your healthcare provider will tell you how much Depakote or Depakene to take and when to take it. Your healthcare provider will tell you how much Depakote or Depakene to take and when to take it. DEPAKOTE ER TABLETS 2. The “ER” in Depakote ER stands for Extended Release. Available in two strengths, Depakote ER contains the same active ingredient as Depakote, (divalproex sodium) but it is designed to slowly deliver the medication over a 24-hour period.